The oncologist
-
Randomized Controlled Trial Multicenter Study
Efficacy and safety of zoledronic acid in patients with breast cancer metastatic to bone: a multicenter clinical trial.
This study evaluated the efficacy and safety of zoledronic acid in breast cancer patients with newly diagnosed bone metastases. ⋯ Breast cancer patients with newly diagnosed bone metastases who were treated with zoledronic acid had a low incidence of SREs compared with patients who received placebo in randomized phase III trials, and pain was decreased from baseline. This study demonstrated the favorable risk:benefit ratio of zoledronic acid for the prevention of skeletal complications.