Medical science monitor : international medical journal of experimental and clinical research
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Comparative Study
Comparison of the local anesthetic effects of chlorpheniramine, midazolam, lidocaine, and normal saline after intradermal injection.
Local anesthetic effects of antihistamines are well known, but have been tested more for diphenhydramine than for chlorpheniramine. Midazolam, a benzodiazepine gamma-aminobutyric acid type A receptor agonist, induces spinally mediated analgesia. However, the local anesthetic effects of chlorpheniramine and midazolain have not been adequately studied. The purpose of this study was to assess the infiltration pain and the local anesthetic effects of intradermial chlorpheniramine and midazolam. ⋯ Intradermal chlorpheniraline, but not midazolam, produced a local anesthetic effect; however, the duration of this effect of chlorpheniramine was shorter than that of lidocaine.
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Comparative Study
Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy.
Magnesium sulfate is used for seizure therapy and prophylaxis in women with eclampsia and preeclampsia worldwide. Magnesium may act by opposing calcium-dependent arterial constriction and may also antagonize the increase in intracellular calcium concentration. The objectives were to study the alterations in serum ionized magnesium and calcium and their relationship in patients with severe pre-eclampsia/eclampsia receiving magnesium sulfate therapy. ⋯ Magnesium ion does not appear to exert its therapeutic effect in pre-eclampsia/eclampsia by substantially modulating serum ionized calcium. However, the effect of exogenous Mg on intracellular calcium cannot be ruled out.
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The study investigated the effect of peak inspiratory flow in a rabbit acute lung injury model. ⋯ Compared with volume-control ventilation with V(T) (20 ml/kg), pressure-regulated volume-control ventilation with the same V(T) worsened oxygenation, histological injury score in tipper lobes, and wet-to-dry ratio in rabbits with injured lungs. The evidence suggests that greater deterioration in gas exchange and lung injury is associated with high inspiratory flow.