Spinal cord
-
Prospective cohort study. ⋯ Recovery of voluntary motor function can be quantitatively tracked using neurophysiological methods in the domains of time and multimuscle motor unit activation.
-
This was an experimental study. ⋯ High-resolution IR-supported PD MRI provides useful micro-anatomical information about white matter damage and sparing in the post-mortem assessment of chronic rat SCI.
-
Female Wistar rats (225 g) underwent spinal cord injury (SCI) at the T4 segment and were assigned to one of the three groups treated with: (1) saline; (2) 7.5 mg kg(-1) Reparixin; or (3) 15 mg kg(-1) Reparixin. Reparixin is a small molecule, allosteric noncompetitive inhibitor of CXCR1 and CXCR2 chemokine receptors involved in inflammation. ⋯ Acute treatment with 15 mg kg(-1) Reparixin reduces acute inflammation and is associated with minor improvements in motor function and a significant reduction in the severity of autonomic dysreflexia.
-
An in vivo study in a rat model of acute spinal cord contusion. ⋯ pNF-H levels may serve as a biomarker for evaluating the efficacy of therapies for SCI.