Spinal cord
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Case series. ⋯ Concentrations of GDNF in CSF are higher in neuropathic pain and appear to be related to stimulation frequency. Further work is needed to evaluate this potential relationship, both in neuropathic pain and in other contexts such as locomotor dysfunction.
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Observational Study
Characterization of spinal subarachnoid bleeding associated to graded traumatic spinal cord injury in the rat.
Observational study in rats subjected to traumatic spinal cord injury (SCI). ⋯ Here, we detail SSB patterns occurring after graded SCI. Further studies are warranted to elucidate the possible role extramedullary events, such as SSB, in the pathophysiology of SCI that might encourage the development of new strategies for its management.
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Prospective study. ⋯ Quantitative MRI analysis may provide reliable information for the prediction of the initial neurological status and surgical outcome of patients with SCIWORET.
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Comparative Study
Translation of the rat thoracic contusion model; part 2 - forward versus backward locomotion testing.
Experimental animal study. ⋯ Our data show that backward locomotion is a highly sensitive and quick test to discriminate between sham, mild and moderate SCI, even after 6 weeks. Backward locomotion testing may improve the translational value of experimental results for the clinic.