Spinal cord
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Review
Global maps of non-traumatic spinal cord injury epidemiology: towards a living data repository.
Literature review. ⋯ Insufficient survival, prevalence and incidence data are a predominant finding of this review. The piecemeal approach to epidemiological reporting of NTSCI, particularly failing to include sound regional population denominators, has exhausted its utility. Minimum data collection standards are required.
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Population modelling--forecasting. ⋯ Understanding the incidence of TSCI is important for health service planning and for the determination of injury prevention priorities. In the absence of high-quality epidemiological studies of TSCI in each country, the estimation of TSCI obtained through population modelling can be used to overcome known deficits in global spinal cord injury (SCI) data. The incidence of TSCI is context specific, and an alternative regression model demonstrated how TSCI incidence estimates could be improved with additional data. The results highlight the need for data standardisation and comprehensive reporting of national level TSCI data. A step-wise approach from the collation of conventional epidemiological data through to population modelling is suggested.
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The objective of this study was to determine the national hospitalization burden of spinal cord injuries (SCIs) among adults in the United States. Factors predicting hospitalization outcomes including length of stay (LOS), total charges and discharge disposition of death were identified. ⋯ There is considerable inpatient burden associated with SCI in the United States. Inpatient LOS, charges and percentage of hospitalizations with discharge disposition of death were higher among individuals with SCI as compared with those without SCI.
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Randomized Controlled Trial Multicenter Study
Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury.
Two randomized, double-blind, placebo-controlled trials. ⋯ Fampridine-SR was well tolerated. No significant differences were observed between treatment groups for the primary end points of Ashworth score and SGI.
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Comparative Study Clinical Trial
Comparison of gait between healthy participants and persons with spinal cord injury when using a powered gait orthosis-a pilot study.
The aim of this study was to evaluate the effect of a powered gait orthosis (PGO) on the temporal-spatial parameters and kinematics of walking in both healthy participants and persons with spinal cord injury (SCI) using three-dimensional motion analysis to facilitate further development of such devices. ⋯ Walking with a PGO by healthy participants significantly reduced critical gait parameters, and further development work is needed to produce a more effective device to match closely the gait parameters of normal walking by healthy participants. Significant differences between normal walking and that evidenced with the PGO by both healthy participants and persons with SCI were detected.