Brain research
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Fos protein expression in retinorecipient suprachiasmatic nucleus (SCN) neurons is a marker of photic entrainment of circadian rhythms. Light-induced Fos in neurons of the intergeniculate leaflet (IGL) is not well-characterized. ⋯ In contrast with light-induced Fos in SCN neurons, Fos-IR was observed in the IGL regardless of circadian time. This work supports the idea that the IGL is involved in transmission of photic information to the SCN in rats.
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Since both REM sleep deprivation and unilateral 6-OHDA lesions induce supersensitivity of DA receptors, the purpose of this study was to determine whether the response of rats with such lesions would be modified by REM sleep deprivation. In addition, the effect of grafts of dissociated chromaffin cells was also tested. ⋯ The results showed that REM sleep deprivation nearly doubled the turning behavior frequency, that chromaffin cell grafts decreased it, but that REM deprivation in grafted animals still seemed to produce an increase of post-synaptic supersensitivity independent of denervation. The results were discussed in terms of the possible relationship of sleep with Parkinson's disease through the DA system.