Brain research
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Neurogenic inflammation (NI) is a feature of several inflammatory pain conditions in which females are overrepresented. Therefore, we asked if there are sex differences in the inflammatory response evoked by well known neurogenic stimuli. We compared the amount of plasma extravasation (PE), a measure of inflammation, in the hindpaw skin of male and female rats caused by subcutaneous injection of capsaicin, application of noxious heat (51 degrees C water bath) or electrical stimulation of the saphenous nerve. ⋯ PE induced by heat was also significantly greater in females compared to males (p<0.001), however, there was no sex-related difference in PE induced by electrical stimulation or by injection of SP. These findings show that females have a greater inflammatory response when inflammation is induced by capsaicin and noxious heat suggesting possible sex-related changes in TRPV-1 receptor mediated mechanisms. These results add to the growing list of sex difference responses to noxious somatic stimulation.
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The spatiotemporal analysis of brain activation during syllogistic reasoning, and the execution of 1 baseline task (BST) were performed in 14 healthy adult participants using high-density event-related brain potentials (ERPs). The following results were obtained: First, the valid syllogistic reasoning task (VSR) elicited a greater positive ERP deflection than the invalid syllogistic reasoning task (ISR) and BST between 300 and 400 ms after the onset of the minor premise. Dipole source analysis of the difference waves (VSR-BST and VSR-ISR) indicated that the positive components were localized in the vicinity of the occipito-temporal cortex, possibly related to visual premise processing. ⋯ Third, both VSR and ISR elicited a more positive ERP deflection than BST between 2500 and 3000 ms. Voltage maps of the difference waves (VSR-BST and VSR-ISR) demonstrated strong activity in the right frontal scalp regions. Results indicate that the reasoning tasks may require more mental effort to spatial processing of working memory.