The journal of obstetrics and gynaecology research
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J. Obstet. Gynaecol. Res. · Jun 1997
Case ReportsPregnancy in a patient of Glanzmann's thrombasthenia with antiplatelet antibodies.
Glanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder. There is an absence of glycoprotein (GP) IIb/IIIa on the platelet membrane which causes reduced platelet aggregation with a defective platelet haemostatic plug formation. ⋯ Pregnancy and delivery is rare in these patients and is associated with a high risk of severe haemorrhage. We describe a primigravida with Glanzmann's thrombasthenia and alloimmunization who developed secondary postpartum haemorrhage and was successfully treated with oral prednisolone.