The journal of obstetrics and gynaecology research
-
J. Obstet. Gynaecol. Res. · Jan 2020
Case ReportsPrimary malignant melanoma of the uterine cervix or vagina which were successfully treated with nivolumab.
Primary malignant melanomas (MM) originating from the gynecological tract are rare. They respond poorly to immunotherapy when compared with cutaneous MM. This study reports two cases. ⋯ The patient was diagnosed as having stage IV vaginal melanoma according to the American Joint Committee on Cancer definition. Both patients received nivolumab therapy, programmed cell death receptor 1 monoclonal antibodies, and the tumors almost disappeared. These cases may add the possibility of using colposcopy with narrow-band imaging and positron-emission tomography to diagnose and evaluate primary MM.