Techniques in coloproctology
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Randomized Controlled Trial Comparative Study
Randomized placebo-controlled trial on local applications of opioids after hemorrhoidectomy.
Hemorrhoidectomy is associated with considerable postoperative pain. This study assessed whether a small dose of morphine or oxycodone administered in the embedded sponge set in the anus at the end of a hemorrhoidectomy intervention reduced postoperative pain. ⋯ The local administration of very low doses of kappa-opioid agonist decreased hemorrhoidectomy postoperative pain through the interaction with specific opioid receptors located on anal mucosa.