The American journal of managed care
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Randomized Controlled Trial Comparative Study Clinical Trial
Effect of rofecoxib therapy on measures of health-related quality of life in patients with osteoarthritis.
Bodily pain and physical disability can negatively impact health-related quality of life (HRQL) in patients with osteoarthritis (OA). ⋯ Rofecoxib treatment increased physical and mental HRQL domain scores on the SF-36. Improvements in mental health with rofecoxib use primarily resulted from effective treatment of OA (i.e., reduction in pain and improvement in physical function).