Respirology : official journal of the Asian Pacific Society of Respirology
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Randomized Controlled Trial
Randomized controlled trial of the effect of regular paracetamol on influenza infection.
Anti-pyretic treatment is recommended in the management of influenza infection. In animal models anti-pyretic treatment increases mortality from influenza. We investigated the effects of paracetamol on viral and clinical outcomes in adults with influenza infection. ⋯ ACTRN12611000497909 at the Australian New Zealand Clinical Trials Registry.
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Randomized Controlled Trial
Effects of low-dose morphine on perceived sleep quality in patients with refractory breathlessness: A hypothesis generating study.
The management of chronic refractory breathlessness is one of the indications for regular low-dose (≤30 mg/24 h) oral sustained release morphine. Morphine may disrupt sleep in some conditions and improve sleep quality in others. This study aimed to determine any signal of regular, low-dose morphine on perceived sleep disruption due to breathlessness and perceived sleep quality. ⋯ Four days of low-dose morphine improved perceived sleep quality in elderly participants with refractory breathlessness. Regular low-dose morphine targeted to reduce refractory breathlessness may yield associated benefits by reducing sleep disruption and improving sleep quality.