Archives of disease in childhood
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Randomized Controlled Trial Clinical Trial
Randomised controlled trial of aminophylline for severe acute asthma.
To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. ⋯ Aminophylline continues to have a place in the management of severe acute asthma in children unresponsive to initial treatment.
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The aim of this study was to determine if children in the community with persistent cough can be considered to have asthma. A validated questionnaire was given to the parents of 1245 randomly selected children aged 6-12 years. ⋯ Although the syndrome commonly referred to as "cough variant asthma" could not be shown in this study, a significant number of children with persistent cough had been diagnosed as having asthma and were treated with asthma medications including inhaled corticosteroids. Studies are urgently needed to determine the appropriate treatment for children with persistent cough.