Archives of disease in childhood
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Transcatheter closure of the patent foramen ovale was the most common interventional procedure performed in our adult congenital heart disease unit in 2006. Although the prevalence of patent foramen ovale is similar in children, closure is rarely performed in this group despite susceptibility to similar defect-related morbidity. In this review we question whether this should remain the case.
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Many drugs are unlicensed in children and consequently their doses have been scaled down from those used in adults. ⋯ Dose scaling should only be used as a last resort for determining a suitable dose in children. No single method was suitable across the entire paediatric age range.