The veterinary journal
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The veterinary journal · Nov 2014
Randomized Controlled TrialEffects of a constant rate infusion of medetomidine-propofol on isoflurane minimum alveolar concentrations in horses.
The aim of this investigation was to determine the isoflurane-sparing effect and impact on arterial blood pressure and anaesthetic recovery of a constant rate infusion of medetomidine-propofol in horses. In a prospective, crossover, randomised study, six healthy horses (mean ± SD age, 13.7 ± 7.7 years; weight, 433 ± 51 kg) were anaesthetised twice with isoflurane and were randomly assigned to receive one of two treatments on each occasion, at least 2 weeks apart. The first treatment was saline (CTL group) and the second a medetomidine-propofol infusion (MP group; 1.25 µg/kg/h medetomidine and 3 mg/kg/h propofol). ⋯ The recovery quality in both groups was considered fair or good and an improvement was observed using the Donaldson scale in the MP group. The administration of a medetomidine-propofol constant rate infusion reduced anaesthetic isoflurane requirements to a clinically significant extent and improved stability of arterial blood pressure together with a good quality recovery. This regime could be useful for providing balanced anaesthesia in horses.