Health technology assessment : HTA
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Health Technol Assess · Jun 2018
Randomized Controlled Trial Multicenter StudyPressure garment to prevent abnormal scarring after burn injury in adults and children: the PEGASUS feasibility RCT and mixed-methods study.
Eleven million people suffer a fire-related injury worldwide every year, and 71% have significant scarring. Pressure garment therapy (PGT) is a standard part of burn scar management, but there is little evidence of its clinical effectiveness or cost-effectiveness. ⋯ We recommend that any future trial include an in-depth mixed-methods recruitment investigation and a process evaluation to account for this.
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Health Technol Assess · Jun 2018
Randomized Controlled Trial Multicenter StudyAlternative tumour necrosis factor inhibitors (TNFi) or abatacept or rituximab following failure of initial TNFi in rheumatoid arthritis: the SWITCH RCT.
Rheumatoid arthritis (RA), the most common autoimmune disease in the UK, is a chronic systemic inflammatory arthritis that affects 0.8% of the UK population. ⋯ How to manage first-line TNFi treatment failures remains unresolved. Had the trial recruited to target, more credible evidence on whether or not either of the interventions were non-inferior to rituximab may have been provided, although this remains speculative.
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Health Technol Assess · Jun 2018
Randomized Controlled TrialDoes progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM).
Progesterone prophylaxis is widely used to prevent preterm birth but is not licensed and there is little information on long-term outcome. ⋯ In this study, progesterone had no significant beneficial or harmful effects on the primary obstetric, neonatal or childhood outcomes.The OPPTIMUM trial is now complete. We intend to participate in a comprehensive individual patient-level data meta-analysis examining women with a singleton pregnancy with a variety of risk factors for preterm birth.
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Health Technol Assess · Jun 2018
Randomized Controlled TrialA pedometer-based walking intervention in 45- to 75-year-olds, with and without practice nurse support: the PACE-UP three-arm cluster RCT.
Guidelines recommend walking to increase moderate to vigorous physical activity (MVPA) for health benefits. ⋯ Exploring different recruitment strategies to increase uptake. Integrating the Pedometer And Consultation Evaluation-UP (PACE-UP) trial with evolving PA monitoring technologies.