Health technology assessment : HTA
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Health Technol Assess · Feb 2021
Randomized Controlled TrialPrehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT.
Acute respiratory failure is a life-threatening emergency. Standard prehospital management involves controlled oxygen therapy. Continuous positive airway pressure is a potentially beneficial alternative treatment; however, it is uncertain whether or not this treatment could improve outcomes in NHS ambulance services. ⋯ A definitive clinical effectiveness trial of continuous positive airway pressure in the NHS is not recommended.
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Health Technol Assess · Feb 2021
Randomized Controlled Trial Multicenter StudyPreoperative intravenous iron for anaemia in elective major open abdominal surgery: the PREVENTT RCT.
Anaemia affects 30-50% of patients before they undergo major surgery. Preoperative anaemia is associated with increased need for blood transfusion, postoperative complications and worse patient outcomes after surgery. International guidelines support the use of intravenous iron to correct anaemia in patients before surgery. However, the use of preoperative intravenous iron for patient benefit has not been assessed in the setting of a formal clinical trial. ⋯ In the preoperative intravenous iron to treat anaemia in major surgery (PREVENTT) trial, all patients included had anaemia and only 20% had their anaemia corrected before surgery. The definition and causality of iron deficiency in this setting is not clear.