Health technology assessment : HTA
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Health Technol Assess · Jul 2019
Randomized Controlled Trial Clinical TrialTranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.
Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. ⋯ Future work should focus on enrolling and treating patients early after stroke and identify which participants are most likely to benefit from haemostatic therapy. Large randomised trials are needed.
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Health Technol Assess · Jul 2019
Randomized Controlled Trial Multicenter Study Clinical TrialAnaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.
Acute otitis media (AOM) is a common reason for primary care consultations and antibiotic prescribing in children. Options for improved pain control may influence antibiotic prescribing and consumption. ⋯ The observed reduction in antibiotic consumption following the prescription of ear drops requires replication in a larger study. Future work should establish if the effect of ear drops is due to pain relief.
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Health Technol Assess · Jul 2019
Randomized Controlled Trial Clinical TrialCultural adaptation of an existing children's weight management programme: the CHANGE intervention and feasibility RCT.
Excess weight in children is a continuing health issue. Community-based children's weight management programmes have had some effect in promoting weight loss. Families from minority ethnic communities are less likely to complete these programmes but, to date, no programmes have been culturally adapted to address this. ⋯ The theoretically informed, culturally adapted children's weight management programme was highly acceptable to children and families of all ethnicities. Consideration should be given to a future trial to evaluate clinical effectiveness and cost-effectiveness of the adapted programme, but the design of a future trial would need to address the logistics of data collection, participant burden and study attrition.
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Health Technol Assess · Jun 2019
Randomized Controlled TrialHPV testing compared with routine cytology in cervical screening: long-term follow-up of ARTISTIC RCT.
The National Screening Committee (NSC) based its recommendation that human papillomavirus (HPV) testing should replace cytology in primary cervical screening largely on the 2009 follow-up results of the ARTISTIC trial (A Randomised Trial In Screening To Improve Cytology). The NSC must now decide on screening intervals and triage policy. Options include extending the screening interval up to 10 years for human papillomavirus-negative (HPV-) women, delaying recall for human papillomavirus-positive (HPV+) women with normal cytology (as their infections are usually transient), and basing triage on full HPV typing. ⋯ This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 28. See the NIHR Journals Library website for further project information.
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Health Technol Assess · Jun 2019
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialNocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT.
Severe asthma exacerbations are costly to patients and the NHS, and occur frequently in severely allergic patients. ⋯ Within the limits of the data, no consistent benefits of the active device were demonstrated, and the differences observed were not sufficient to make the device cost-effective. The types of patients who may benefit from the TLA device, and the reasons for large reductions in exacerbation frequency in severe asthma trials, which also incorporate other methods of recording exacerbations, need to be explored.