Biochemical and biophysical research communications
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Biochem. Biophys. Res. Commun. · Mar 1997
Comparative StudyNa+/K+ ATPase in lower airway epithelium from cystic fibrosis and non-cystic-fibrosis lung.
The basolateral Na+/K+ ATPase plays a critical role in sodium reabsorption across airway epithelium. Nasal epithelium shows increased Na+/K+ ATPase activity in cystic fibrosis (CF) but Na+/K+ ATPase has not been characterized in human lung epithelium or compared in CF and normal lung. ⋯ Bronchial epithelial Na+/K+ ATPase activity was twofold higher in CF patients than in controls. The increased Na+/K+ ATPase activity may contribute to the increased sodium reabsorption seen in cystic fibrosis.