International journal of pharmaceutical compounding
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United States Pharmacopeia Chapter 797 provides guidelines and standards that deal with the preparation, compounding, and labeling of compounded sterile preparations. These standards ensure patient care and safety by defining safe practice. ⋯ Each of these categories has specific aspects of environmental personnel, and situational deterrents that Chapter 797 requires to be taken into account. By following the standards of Chapter 797, compounding pharmacists can alleviate danger to the patient and themselves in any situation.
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The chemical stability of an intrathecally administered analgesic combination may influence the frequency of pump refills necessary to maintain safe and effective analgesia. Previous work has shown that the stability of ziconotide at body temperature is reduced substantially by the presence of morphine sulfate 35 mg/mL. The current study was performed to evaluate the chemical stability of admixtures combining ziconotide with lower concentrations of morphine sulfate during simulated intrathecal infusion under laboratory conditions at 37 deg C. ⋯ Morphine sulfate 10 mg/mL, the mean ziconotide concentration declined to 81.4% of the initial concentration in 60 days, and 90% and 80% stabilites were maintained for 34 days and 65 days, respctively. In the admixture containing morphine sulfate 20 mg/mL, the mean ziconotide concentration declined to 85.3% of the initial concentration in 28 days, and 90% and 80% stabilities were maintained for 19 days and 37 days, respectively. Decreasing the concentration of morphine in an admixture containing ziconotide improves the stablity of ziconotide.