The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · Jun 2011
Randomized Controlled Trial Multicenter StudyResults at 30 months of a randomised trial of two 8-month regimens for the treatment of tuberculosis.
An 8-month isoniazid (INH, H) and ethambutol (EMB, E) based regimen recommended by the World Health Organization (WHO) had never been evaluated in a randomised controlled multicentre trial. ⋯ These results confirm earlier findings demonstrating the inferiority of the INH+EMB-based regimens to the standard 6-month regimen. The WHO has withdrawn its recommendation of these regimens.
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Int. J. Tuberc. Lung Dis. · Jun 2011
Randomized Controlled TrialRisk of tuberculosis among contacts of isoniazid-resistant and isoniazid-susceptible cases.
To compare the risk to household contacts of isoniazid (INH) susceptible and INH-resistant cases of tuberculosis (TB) in a rural community in South India. ⋯ The baseline prevalence of tuberculous infection was substantially higher in contacts of INH-resistant than INH-susceptible patients, but the incidence of tuberculous disease over a 15-year follow-up was similar in the two series, and twice as high as in non-contacts.