The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · Nov 2010
ReviewAge-related risk of hepatotoxicity in the treatment of latent tuberculosis infection: a systematic review.
To determine the age-related risk of hepatotoxicity under currently recommended treatment regimens for latent tuberculosis (TB) infection (LTBI). ⋯ The rates of hepatotoxicity were low. Summary estimates of risks generated in this review can be used for counselling individuals for whom chemoprophylaxis is recommended. The use of INH for the treatment of LTBI is safe in older patients with clinical or biochemical monitoring.
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Eleven referring hospitals in South Korea. ⋯ We identified three phenotypes in elderly subjects with OLD. Follow-up studies are needed to explore the clinical significance of each phenotype.
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Int. J. Tuberc. Lung Dis. · Oct 2010
Extensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa.
Extensively drug-resistant tuberculosis (XDR-TB) has been documented worldwide, but reports of XDR-TB in children are extremely limited. ⋯ XDR-TB is a microbiologic diagnosis that, even with HIV co-infection, can be successfully identified. Concurrent XDR-TB and HIV therapy is feasible and effective in children, although more research is needed into potential overlapping toxicities. Nosocomial transmission is suggested, calling for infection control policies in pediatric wards.
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Int. J. Tuberc. Lung Dis. · Oct 2010
Multicenter Study Comparative StudyMinocycline and talc slurry pleurodesis for patients with secondary spontaneous pneumothorax.
Few studies have evaluated the sclerosing efficacy of minocycline, and none have specifically compared its sclerosing efficacy and safety profiles with talc slurry in secondary spontaneous pneumothorax (SSP). ⋯ Minocycline and talc slurry had comparable sclerosing efficacy in SSP, with immediate success rates of >70%. Pain was the most common adverse effect and respiratory distress was uncommon. Both appeared to be effective and safe for chemical pleurodesis in SSP.
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Domestic pollution is relevant to health because people spend most of their time indoors. One half of the world's population is exposed to high concentrations of solid fuel smoke (biomass and coal) that are produced by inefficient open fires, mainly in the rural areas of developing countries. ⋯ Other tobacco smoke-associated diseases, such as tuberculosis, asthma, respiratory tract cancer and interstitial lung diseases, may also be associated with solid fuel smoke inhalation, but evidence is limited. As the desirable change to clean fuels is unlikely, efforts have been made to use efficient, vented wood or coal stoves, with varied success due to inconsistent acceptance by the community.