The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · May 2016
Pharmacokinetics of isoniazid, rifampicin, pyrazinamide and ethambutol in HIV-infected Indian children.
Co-infection with the human immunodeficiency virus (HIV) may lead to inadequate plasma concentrations of anti-tuberculosis drugs in children with tuberculosis (TB). ⋯ Inadequate concentrations of INH, RMP and EMB in both HIV-TB-infected and non-HIV-infected children provide support for the recently revised recommended doses of INH and RMP. EMB levels were lower in HIV-infected children; however, more studies are needed to validate this observation.
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Int. J. Tuberc. Lung Dis. · Apr 2016
Comparative StudyMortality and predictors in pulmonary tuberculosis with respiratory failure requiring mechanical ventilation.
To analyse the predictors and mortality rate among patients receiving mechanical ventilation (MV) for respiratory failure due to pulmonary tuberculosis (TB). ⋯ TB patients showed identical SOFA and APACHE II scores, but higher mortality than CAP patients. The higher mortality was not related to severity, but suggested an association with the extent of destructive lung lesions.
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Int. J. Tuberc. Lung Dis. · Mar 2016
Unsupervised learning technique identifies bronchiectasis phenotypes with distinct clinical characteristics.
Unsupervised learning technique allows researchers to identify different phenotypes of diseases with complex manifestations. ⋯ Identification of distinct phenotypes will lead to greater insight into the characteristics and prognosis of bronchiectasis.
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Int. J. Tuberc. Lung Dis. · Mar 2016
Market assessment of tuberculosis diagnostics in India in 2013.
India represents a significant potential market for new tests. We assessed India's market for tuberculosis (TB) diagnostics in 2013. ⋯ India's estimated market value for TB diagnostics in 2013 was US$70.8 million. These data should be of relevance to test developers, donors and implementers.
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Int. J. Tuberc. Lung Dis. · Feb 2016
Anaemia in patients with HIV-associated TB: relative contributions of anaemia of chronic disease and iron deficiency.
Anaemia commonly complicates both human immunodeficiency virus (HIV) infection and tuberculosis (TB), contributing substantially to morbidity and mortality. The mechanisms underlying anaemia and corresponding treatments in co-infected patients are poorly defined. ⋯ ACD was the predominant cause underlying anaemia in HIV-associated TB patients, and IDA was very uncommon in this setting. The majority of anaemic HIV-associated TB patients were unlikely to benefit from oral iron supplementation.