Clinical and experimental nephrology
-
Clin. Exp. Nephrol. · Aug 2011
Predictors of acute kidney injury post-cardiopulmonary bypass in children.
To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU). ⋯ AKI is common and occurred in 11% of our patients following CPB; however, AKI requiring renal replacement therapy is uncommon.
-
Clin. Exp. Nephrol. · Aug 2011
ReviewLung injury following acute kidney injury: kidney-lung crosstalk.
The mortality of acute kidney injury (AKI) remains unacceptably high, especially associated with acute respiratory failure. Lung injury complicated with AKI was previously considered as "uremic lung", which is characterized by volume overload and increased vascular permeability. ⋯ In this review, we outline the history of uremic lung and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), the epidemiological data on the synergistic effect of AKI and lung injury on mortality, and recent basic research which has identified possible pathways in AKI-induced lung injury. These findings will enable us to develop new therapeutic strategies against lung injury associated with AKI and improve the outcomes of critically ill patients in intensive care units.
-
Clin. Exp. Nephrol. · Aug 2011
Measurements of serum cystatin C concentrations underestimate renal dysfunction in pediatric patients with chronic kidney disease.
In our clinical experience, cystatin C (CysC) concentrations are not as high as expected in patients with chronic kidney disease (CKD) and high-stage renal dysfunction. We therefore investigated whether measurements of serum CysC result in an underestimation of renal dysfunction in pediatric patients with CKD. ⋯ Measurements of serum CysC concentrations lead to underestimation of renal dysfunction in pediatric patients with CKD.