Clinical and experimental nephrology
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Clin. Exp. Nephrol. · Feb 2012
Hypervolemic hypernatremia in patients recovering from acute kidney injury in the intensive care unit.
A high incidence of hypernatremia is often observed in patients recovering from acute kidney injury (AKI) in intensive care units. ⋯ The hypernatremia is believed to be due to post-AKI diuresis in the face of inability to maximally concentrate the urine because of renal failure. The diuresis caused a disproportionate loss of water in excess of that of sodium in the absence of replenishment of the water loss. Additionally, the patients were hypervolemic due to the retention of large quantities of sodium and water as a result of infusion of substantial volumes of physiological saline prior to the development of hypernatremia.