Clinical and experimental nephrology
-
Clin. Exp. Nephrol. · Aug 2017
Review Meta AnalysisTiming of initiation of renal replacement therapy for acute kidney injury: a systematic review and meta-analysis of randomized-controlled trials.
The effects of early renal replacement therapy (RRT) on mortality and renal recovery in patients with acute kidney injury (AKI) remain controversial. A systematic review and meta-analysis of randomized-controlled trials (RCTs) was performed. ⋯ Early initiation of RRT for patients with AKI is not associated with decreased overall mortality or a delayed renal recovery rate. The optimal time to initiate RRT remains uncertain. Large scale and adequately powered RCTs are needed to detect the effects of early initiation of RRT in AKI patients.
-
Clin. Exp. Nephrol. · Aug 2017
Comparative StudyComparison of oral steroids with tonsillectomy plus steroid pulse therapy in patients with IgA nephropathy.
Treatment of IgA nephropathy (IgAN) in Japan has recently changed, from oral prednisolone (oPSL) to tonsillectomy plus steroid pulse (TSP) therapy. However, a few studies have compared their efficacy and safety. ⋯ CR rates are higher; protection of renal function and prevention from adverse events were superior with TSP than with oPSL in patients with IgAN and moderate-to-severe proteinuria.
-
Clin. Exp. Nephrol. · Aug 2017
Predictors of relapse and long-term outcome in children with steroid-dependent nephrotic syndrome after rituximab treatment.
In patients with complicated steroid-dependent nephrotic syndrome (SDNS), rituximab (RTX) followed by immunosuppressive agent (IS) can maintain remission without the use of prednisolone (PSL). However, available data on the predictive factors for relapse and the long-term outcome after this protocol are few. ⋯ The introduction of RTX may not be necessarily associated with improved long-term outcome.