CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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Multicenter Study
Does early surgical repair of hip fractures improve patient outcomes?
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Multicenter Study
Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies.
Antibiotic disruption of the normal intestinal flora is a well-known risk factor for Clostridium difficile-associated diarrhea. Reduced gastric acidity has been suggested as a risk factor, and we hypothesized that proton pump inhibitors, because of their potency, may be an independent risk factor for this problem. ⋯ Patients in hospital who received proton pump inhibitors were at increased risk of C. difficile diarrhea.