CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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Review Meta Analysis Comparative Study
Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis.
Recent guidelines suggest lowering the target blood pressure for patients with chronic kidney disease, although the strength of evidence for this suggestion has been uncertain. We sought to assess the renal and cardiovascular effects of intensive blood pressure lowering in people with chronic kidney disease. ⋯ Intensive blood pressure lowering appears to provide protection against kidney failure events in patients with chronic kidney disease, particularly among those with proteinuria. More data are required to determine the effects of such a strategy among patients without proteinuria.