British journal of anaesthesia
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Clinical Trial Controlled Clinical Trial
Anaesthesia for Caesarean section. Analysis of blood concentrations of halothane using 0.2% or 0.65% halothane with 50% nitrous oxide in oxygen.
In 15 patients anaesthesia for elective Caesarean section was maintained with 50% nitrous oxide in oxygen and a 0.65% halothane supplement. In a further 15 mothers a 0.2% halothane supplement was used. In those mothers receiving 0.65% halothane intermittent measurements were made of maternal arterial halothane concentrations during the uptake and the excretion of the agent. ⋯ The use of 0.2% and 0.65% halothane supplements prevented awareness in all the mothers. However, dreaming occurred in two patients given a 0.2% halothane supplement. Studies are required to establish the minimum halothane supplement required to prevent awareness in a larger series of patients.
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The oral administration of dantrolene for the prophylaxis of malignant hyperthermia (MH) in susceptible swine has been investigated. Complete protection from MH in pigs exposed to the known MH initiating agents, halothane and suxamethonium, was demonstrated.