British journal of anaesthesia
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Comparative Study Clinical Trial Controlled Clinical Trial
Comparison of the actions of diazepam and lorazepam.
Diazepam and lorazepam differ in potency and in the time-course of their action. As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. ⋯ Lorazepam is more effective than diazepam in blocking the emergence sequelae from ketamine. Lorazepam i.v. is followed by a lesser frequency of venous thrombosis.
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The effects on the circulation of limited normovolaemic haemodilution with dextran 70 and subsequent haemorrhage to a mean arterial pressure of 60 mm Hg were studied with isotope-labelled microspheres in the dog. Following haemodilution, cardiac output, stroke volume and systemic oxygen transport increased. ⋯ Blood flow was redistributed to maintain the cerebral, renal, hepatic arterial and coronary circulations, mainly at the expense of blood flow to the carcass and through systemic arterio-venous shunts. Thus, limited normovolaemic haemodilution does not affect the normal circulatory response to moderate haemorrhagic hypotension.