British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Effect of adrenaline on extradural anaesthesia and plasma bupivacaine concentrations during caesarean section.
The effect of adrenaline on the efficacy of extradural block and plasma bupivacaine concentrations was investigated in women undergoing elective (n = 40) and emergency (n = 40) Caesarean section. Patients were randomly allocated within these two groups to receive 0.5% bupivacaine 20 ml either plain or with adrenaline 1 in 200,000, as a single fractionated extradural injection. The elective plain group needed significantly more supplementary analgesia compared with the other three groups (P less than 0.05). ⋯ In the emergency group, there were no significant differences in plasma bupivacaine concentrations between the plain and adrenaline subgroups. Maximum plasma concentrations correlated significantly (P less than 0.0001) with dose of bupivacaine (mg kg-1). It is concluded that extradural adrenaline does not usefully reduce systemic absorption of 0.5% bupivacaine, but may improve its efficacy in extradural anaesthesia for elective Caesarean section.
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Anterior fontanelle pressure responses to tracheal intubation in the awake and anaesthetized infant.
In order to define the changes in intracranial pressure which occur during tracheal intubation in young infants, a Ladd transducer was used to monitor anterior fontanelle pressure (AFP) non-invasively in awake (group 1, n = 14) and anaesthetized (group 2, n = 10) infants during intubation of the trachea. Heart rate and systolic arterial pressure were also recorded. In quiet, undisturbed infants, AFP (mean +/- SEM) was similar in groups 1 (9.6 +/- 0.5 mm Hg) and 2 (8.7 +/- 0.8 mm Hg); with crying, AFP increased significantly in both groups. ⋯ Neither heart rate nor systolic arterial pressure changed significantly in either group during laryngoscopy--when compared with measurements in the quiet state. It was concluded that AFP increases significantly during intubation and during crying in the infant. The response to intubation is only partially attenuated by the prior administration of general anaesthesia.
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Randomized Controlled Trial Clinical Trial
Posture and post-spinal headache. A controlled trial in 80 obstetric patients.
Eighty obstetric patients receiving subarachnoid anaesthesia for second and third stage procedures, excluding Caesarean section, were studied. They were randomly allocated postpartum to either 24 h bed rest or early (6 h post spinal) mobilization. ⋯ There was a significantly greater incidence of severe spinal headaches in the "bed-rest" group and three patients in this group required blood patch treatment for their headache. Early mobilization is, therefore, the recommended management after spinal anaesthesia for these types of obstetric procedure.
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Case Reports
Muscle relaxation in patients with Duchenne's muscular dystrophy. Use of vecuronium in two patients.
Cumulative 50% and 90% neuromuscular blocking doses of vecuronium were determined in two 4-yr-old boys with Duchenne's muscular dystrophy. Vecuronium 20 micrograms kg-1 was required for 50% twitch depression in both patients. The 90% blocking doses were 43 and 57 micrograms kg-1. ⋯ Thus, the titration of the individual neuromuscular blocking dose with the aid of a nerve stimulator is mandatory. During a previous anaesthetic, cardiac arrest and acute rhabdomyolysis had occurred in one patient. The substitution of suxamethonium by vecuronium, or probably any other non-depolarizing myoneural blocking drug of intermediate or short duration of action, may help to avoid this complication.