British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Effect of diluting propofol on the incidence of pain on injection and venous sequelae.
The effect of diluting propofol in 5% dextrose on the incidence of i.v. injection pain was studied in 100 adult patients. Severe injection pain occurred in 32% (16 patients) who received undiluted propofol, compared with 10% (five patients) who received dilute propofol. We concluded that the dilution of propofol significantly reduced the incidence of severe pain during injection without increasing postoperative venous sequelae.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of continuous paravertebral and extradural infusions of bupivacaine for pain relief after thoracotomy.
Pain was controlled in 20 post-thoracotomy patients using a continuous infusion of 0.25% bupivacaine through an extradural or para-vertebral catheter. Both techniques provided good analgesia. Hypotension and urine retention occurred significantly less frequently in the paravertebral than in the extradural group.
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Randomized Controlled Trial Comparative Study Clinical Trial
Changes in oxygen saturation during inhalation induction of anaesthesia in children.
Changes in oxygen saturation (SaO2) were studied during induction of anaesthesia in 48 healthy children receiving halothane or isoflurane for outpatient dental extractions. Substantial reductions in SaO2 occurred in more than 50% of the children given isoflurane and were associated with the irritant effects of this agent on the airway. SaO2 was largely unaltered during the use of halothane. These findings indicate that the airway complications caused by isoflurane may be associated with decreases in SaO2.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of 1.5% enflurane with 1.25% isoflurane in oxygen for caesarean section: avoidance of awareness without nitrous oxide.
We examined the feasibility of administering nearly 100% oxygen throughout the induction-delivery period of general anaesthesia for 113 Caesarean sections. Isoflurane 1.25% was compared with 1.5% enflurane for maintenance of anaesthesia. ⋯ The three main criteria for a satisfactory general anaesthetic technique for Caesarean section were fulfilled, namely no maternal awareness, no undue depression of the fetus and no adverse effect on uterine contractility. Isoflurane and enflurane appear to be suitable anaesthetic agents for facilitating hyperoxygenation during Caesarean section.
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We report two cases of ventricular arrest with persisting atrial activity in association with propofol anaesthesia. In both cases, anticholinergic agents corrected the arrhythmia. It is recommended that anticholinergic drugs be given routinely when propofol is used in association with vagal stimulants.