British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements.
The present randomized, placebo-controlled, double-blind study was designed to assess the effect of peroperatively administered i.v. magnesium sulphate on anaesthetic and analgesic requirements during total i.v. anaesthesia. ⋯ The administration of magnesium led to a significant reduction in the requirements for anaesthetic drugs during total i.v. anaesthesia with propofol, remifentanil and vecuronium.
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Randomized Controlled Trial Comparative Study Clinical Trial
Remifentanil or propofol for sedation during carotid endarterectomy under cervical plexus block.
During carotid endarterectomy under regional anaesthesia, patients often require medication to control haemodynamic instability and to provide sedation and analgesia. Propofol and remifentanil are used for this purpose. However, the benefits, side-effects, and optimal dose of these drugs in such patients are unclear. ⋯ As a result of the higher incidence of adverse respiratory effects with remifentanil and similar sedative effects, propofol is preferable for sedation during cervical plexus block in elderly patients with comorbid disease at the dosage used.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized, double-blind comparison of different inspired oxygen fractions during general anaesthesia for Caesarean section.
The optimal inspired oxygen fraction FI(O(2)) for fetal oxygenation during general anaesthesia for Caesarean section is not known. ⋯ Use of FI(O(2)) 1.0 during general anaesthesia for elective Caesarean section increased fetal oxygenation.
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Randomized Controlled Trial Comparative Study Clinical Trial
Remifentanil compared with sufentanil during extra-corporeal shock wave lithotripsy with spontaneous ventilation: a double-blind, randomized study.
The pharmacokinetic properties of remifentanil may allow a rapid analgesic action during painful procedures and short lasting postoperative respiratory depression. ⋯ A continuous i.v. infusion of remifentanil provided comparable analgesia and caused less respiratory depression and nausea and vomiting than i.v. boluses of sufentanil in patients undergoing extra-corporeal shock wave lithotripsy.
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Randomized Controlled Trial Clinical Trial
Epinephrine and clonidine do not improve intrathecal sufentanil analgesia after total hip replacement.
We compared analgesia after intrathecal sufentanil alone, sufentanil with epinephrine 200 microg and sufentanil with clonidine 30 microg in patients after total hip replacement, the endpoints being onset and duration of action. ⋯ After total hip replacement, all three analgesic regimens gave good analgesia with comparable onset and duration of action, and minor adverse effects.