British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements.
The present randomized, placebo-controlled, double-blind study was designed to assess the effect of peroperatively administered i.v. magnesium sulphate on anaesthetic and analgesic requirements during total i.v. anaesthesia. ⋯ The administration of magnesium led to a significant reduction in the requirements for anaesthetic drugs during total i.v. anaesthesia with propofol, remifentanil and vecuronium.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized, double-blind comparison of different inspired oxygen fractions during general anaesthesia for Caesarean section.
The optimal inspired oxygen fraction FI(O(2)) for fetal oxygenation during general anaesthesia for Caesarean section is not known. ⋯ Use of FI(O(2)) 1.0 during general anaesthesia for elective Caesarean section increased fetal oxygenation.
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Randomized Controlled Trial Comparative Study Clinical Trial
Remifentanil compared with sufentanil during extra-corporeal shock wave lithotripsy with spontaneous ventilation: a double-blind, randomized study.
The pharmacokinetic properties of remifentanil may allow a rapid analgesic action during painful procedures and short lasting postoperative respiratory depression. ⋯ A continuous i.v. infusion of remifentanil provided comparable analgesia and caused less respiratory depression and nausea and vomiting than i.v. boluses of sufentanil in patients undergoing extra-corporeal shock wave lithotripsy.
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Randomized Controlled Trial Comparative Study Clinical Trial
Remifentanil or propofol for sedation during carotid endarterectomy under cervical plexus block.
During carotid endarterectomy under regional anaesthesia, patients often require medication to control haemodynamic instability and to provide sedation and analgesia. Propofol and remifentanil are used for this purpose. However, the benefits, side-effects, and optimal dose of these drugs in such patients are unclear. ⋯ As a result of the higher incidence of adverse respiratory effects with remifentanil and similar sedative effects, propofol is preferable for sedation during cervical plexus block in elderly patients with comorbid disease at the dosage used.
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Comparative Study
Comparison of ocular microtremor and bispectral index during sevoflurane anaesthesia.
A practical and reliable monitor of depth of anaesthesia would be a major advance on current clinical practice. None of the present monitors is both simple to use and accurate. Ocular microtremor (OMT) is a physiological tremor that is suppressed by propofol in a dose-dependent manner. We studied OMT during propofol induction and nitrous oxide-oxygen-sevoflurane maintenance of anaesthesia in 30 patients, and compared OMT with the bispectral index (BIS) as a predictor of response to verbal command. ⋯ OMT is suppressed by sevoflurane and accurately predicts response to verbal command. OMT may be a useful monitor of depth of hypnosis.