British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Does the opioid-sparing effect of rectal diclofenac following total abdominal hysterectomy benefit the patient?
The aim of this prospective, double-blind, randomized, placebo-controlled clinical trial was to investigate the opioid-sparing effects of rectal diclofenac following total abdominal hysterectomy. ⋯ Rectal diclofenac reduces morphine consumption, improves postoperative analgesia, and reduces the incidence of adverse effects such as sedation and nausea.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of articaine and bupivacaine/lidocaine for peribulbar anaesthesia by inferotemporal injection.
Articaine is a novel amide local anaesthetic with a shorter duration of action than prilocaine. ⋯ Two per cent articaine is safe and effective for peribulbar anaesthesia by inferotemporal injection and is a suitable alternative to the traditional mixture of 0.5% bupivacaine and 2% lidocaine.
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Randomized Controlled Trial Clinical Trial
Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design.
Despite intensive research, the main causes of postoperative nausea and vomiting (PONV) remain unclear. We sought to quantify the relative importance of operative, anaesthetic and patient-specific risk factors to the development of PONV. ⋯ Volatile anaesthetics were the leading cause of early postoperative vomiting. The pro-emetic effect was larger than other risk factors. In patients at high risk for PONV, it would therefore make better sense to avoid inhalational anaesthesia rather than simply to add an antiemetic, which may still be needed to prevent or treat delayed vomiting.