British journal of anaesthesia
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The commercial propofol preparation in an intralipid solution causes marked vasodilatation. Both propofol and its solvent seem to stimulate the nitric oxide (NO) pathway. The role of intralipid in cardiac and regional haemodynamic changes induced by propofol and their respective interactions with the NO pathway was assessed. ⋯ Except for the coronary and carotid circulations, intralipid modulates the NO pathway in cardiac and regional blood flow.