British journal of anaesthesia
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Multicenter Study
Constipation and its implications in the critically ill patient.
Motility of the lower gut has been little studied in intensive care patients. ⋯ Constipation has implications for the critically ill.
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Case Reports
Non-invasive ventilation to avoid tracheal intubation in a patient with Guillain-Barré syndrome.
A 72-yr-old man presented with respiratory failure secondary to Guillain-Barré syndrome. Although the criteria for mechanical ventilation were satisfied, the absence of weakness of the bulbar muscles allowed the safe use of non-invasive ventilation for 2 weeks in this patient. Invasive ventilation and tracheostomy were avoided and the patient made a good recovery.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized, controlled, cross-over clinical trial comparing intravenous midazolam sedation with nitrous oxide sedation in children undergoing dental extractions.
The use of benzodiazepines for paediatric dental sedation has received limited attention with regard to research into clinical effectiveness. A study was therefore designed to investigate the use of midazolam, for i.v. sedation in paediatric dental patients. ⋯ I.V. midazolam sedation (0.5 mg x min(-1) to a maximum of 5 mg) appears to be as effective as nitrous oxide sedation in 12-16-yr-old healthy paediatric dental patients.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery.
Balanced postoperative analgesia combines non-narcotic drugs and opioids. We organized a large study to evaluate nefopam analgesia and tolerance in combination with morphine for patient-controlled analgesia (PCA) after orthopaedic surgery. ⋯ In combination with PCA morphine, nefopam gives significant morphine-sparing with lower immediate postoperative pain scores without major side-effects. This analgesic effect seems to be particularly notable for patients with intense preoperative pain.