British journal of anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized double-blind clinical trial comparing topical and sub-Tenon's anaesthesia in routine cataract surgery.
Several local anaesthetic techniques are available for cataract surgery. Recently, topical anaesthesia has gained in popularity. A randomized trial was designed to compare patient discomfort and intraoperative complications following routine cataract surgery under topical or sub-Tenon's anaesthesia. ⋯ Patients undergoing cataract surgery under topical anaesthesia experience more postoperative discomfort than patients receiving sub-Tenon's anaesthesia. Surgery-related complications were similar in both groups.
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Randomized Controlled Trial Clinical Trial
Small dose of clonidine mixed with low-dose ropivacaine and fentanyl for epidural analgesia after total knee arthroplasty.
We studied whether a small dose of clonidine added to a ropivacaine-fentanyl mixture improves epidural analgesia without provoking side effects typically related to larger amounts of epidural clonidine. ⋯ The small amount of clonidine added to the low-dose ropivacaine-fentanyl mixture reduced the need for opioid rescue pain medication after TKA. Clonidine slightly decreased arterial pressure and heart rate without jeopardizing haemodynamics. Otherwise, the side effect profiles were comparable in both groups.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of hyperbaric and plain ropivacaine 15 mg in spinal anaesthesia for lower limb surgery.
Previously, plain ropivacaine 15 mg given intrathecally has been shown to be feasible for ambulatory surgery of lower-extremities. Hypothetically, hyperbaric solution could improve and shorten the block. ⋯ In comparison with the plain solution, 15 mg of intrathecal hyperbaric ropivacaine produced a faster onset, greater success rate of analgesia at the level of T(10) dermatome, and faster recovery of the block.
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Randomized Controlled Trial Comparative Study Clinical Trial
Spectral entropy measurement of patient responsiveness during propofol and remifentanil. A comparison with the bispectral index.
We compared two spectral entropies, state entropy (SE) and response entropy (RE), based on the irregularity of the EEG, to measure loss of response to verbal command (LOR(verbal)) and noxious stimulus (LOR(noxious)) with the bispectral index (BIS) during propofol infusion with and without remifentanil. ⋯ LOR(verbal) was detected accurately by BIS, SE and RE except for 100% sensitivity, where BIS performed better. Though BIS, SE and RE were influenced by remifentanil during propofol administration, their ability to detect LOR(verbal) remained accurate. None of the measures predicted LOR(noxious).
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Randomized Controlled Trial Clinical Trial
Target concentrations of remifentanil with propofol to blunt coughing during intubation, cuff inflation, and tracheal suctioning.
The target blood concentrations of propofol and remifentanil, when used in combination, required to blunt the cough response to tracheal intubation, cuff inflation, and tracheal suctioning without neuromuscular blocking agents are not known. ⋯ Target remifentanil blood concentrations of 5, 10, and 15 ng ml(-1) associated with a 3.5 microg ml(-1) propofol target blood concentration provided good intubating conditions and absence of cough about 75% of the time. Higher target remifentanil concentrations were associated with less coughing during tracheal tube cuff inflation and tracheal suctioning.