British journal of anaesthesia
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Comparative Study
Does manual anaesthetic record capture remove clinically important data?
Numerous studies have shown smoothing and inaccuracies in handwritten anaesthetic records, but the clinical relevance of these findings is unclear. We therefore sought to determine whether the behaviour of anaesthetists differed in assessing anaesthetic records re-synthesized from either handwritten or automated records. ⋯ In comparison with computerized record-keeping, manual record-keeping resulted in loss of clinically relevant information.
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Comparative Study
Performance evaluation of paediatric propofol pharmacokinetic models in healthy young children.
The performance of eight currently available paediatric propofol pharmacokinetic models in target-controlled infusions (TCIs) was assessed, in healthy children from 3 to 26 months of age. ⋯ Our results suggest that six of the eight models tested perform well in young children. Since most models overestimate the initial volume of distribution, the use for TCI might result in the administration of larger bolus doses than necessary.
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Angiotensin II (Ang II) induces oxidative stress and apoptosis in vascular endothelial cells. We hypothesized that propofol may attenuate Ang II-induced apoptosis in human coronary artery endothelial cells (HCAECs) and aimed to identify the underlying mechanisms. ⋯ Propofol protected HCAECs from Ang II-induced apoptosis by interfering with the generation of oxidative stress and redox-sensitive apoptotic pathways.
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Review Meta Analysis
Efficacy and adverse effects of ketamine as an additive for paediatric caudal anaesthesia: a quantitative systematic review of randomized controlled trials.
This meta-analysis included 13 studies and demonstrates that ketamine added to caudal local anaesthesia prolongs analgesia in children with minimal adverse effects, though highlights that the potential neurotoxicity of ketamine has not yet been conclusively addressed.
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