British journal of anaesthesia
-
Pulse pressure variation (PPV) and systolic pressure variation (SPV) are reliable predictors of fluid responsiveness in patients undergoing controlled mechanical ventilation. Currently, PPV and SPV are measured invasively and it is unknown if an arterial pressure (AP) signal obtained with a finger cuff can be used as an alternative. The aim of this study was to validate PPV and SPV measured using a finger cuff. ⋯ In patients receiving controlled mechanical ventilation after CABG, PPV and SPV can be measured reliably non-invasively using the inflatable finger cuff of the Nexfin™ monitor.
-
Desflurane triggers post-conditioning in the diabetic human myocardium. We determined whether protein kinase C (PKC), mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channels, Akt, and glycogen synthase kinase-3β (GSK-3β) were involved in the in vitro desflurane-induced post-conditioning of human myocardium from patients with type 2 diabetes. ⋯ Desflurane-induced post-conditioning in human myocardium from patients with type 2 diabetes was mediated by the activation of PKC, the opening of the mitoK(ATP) channels, and the phosphorylation of Akt and GSK-3β.
-
Central venous catheter (CVC) placement under ECG guidance in the left thoracocervical area can lead to catheter misplacement. The aim of this study was to identify the cause and quantify the magnitude of this error. ⋯ CVC placement under ECG guidance is a reliable method to site the line tip at the optimal position. However, when using a left-sided thoracocervical access point, the Seldinger wire-conducted ECG delivered a constant error. This could be adjusted for by advancing the CVC 20 mm in addition to the wire-based measurement of the insertion depth at the left IJ vein and 10 mm at the left SC vein.