British journal of anaesthesia
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Review Meta Analysis
Non-opioid analgesics in adults after major surgery: systematic review with network meta-analysis of randomized trials.
Morphine, and analgesics other than morphine (AOM), are commonly used to treat postoperative pain after major surgery. However, which AOM provides the best efficacy-safety profile remains unclear. ⋯ PROSPERO: CRD42013003912.
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Review Meta Analysis
Effect of beta-blockers on perioperative outcomes in vascular and endovascular surgery: a systematic review and meta-analysis.
To investigate the role of perioperative beta-blocker use in vascular and endovascular surgery. ⋯ Beta-blockers do not improve perioperative outcomes in vascular and endovascular surgery.
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Human error poses significant risk for hospitalized patients causing an estimated 100,000 to 400,000 deaths in the USA annually. Medication errors contribute, with error occurring in 5.3% of medication administrations during surgery. In this study 70.3% of medication errors were deemed preventable. ⋯ There are few rigorous studies to direct medication safety strategies, but this should not lead us to do nothing. The overwhelming consensus regarding best practices should be accepted, and the recommendations implemented. Our list of recommended strategies can hopefully be used to assess local vulnerabilities and institute system solutions.
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This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.
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Randomized Controlled Trial
Chewing gum for the treatment of postoperative nausea and vomiting: a pilot randomized controlled trial.
A novel treatment, chewing gum, may be non-inferior to ondansetron in inhibiting postoperative nausea and vomiting (PONV) in female patients after laparoscopic or breast surgery. In this pilot study, we tested the feasibility of a large randomized controlled trial. ⋯ Australian New Zealand Clinical Trials Registry: ACTRN12615001327572.