British journal of anaesthesia
-
Heterogeneity among the primary studies included in a systematic review (SR) is one of the most challenging considerations for systematic reviewers. Current practices in anaesthesiology SRs have not been evaluated, but traditional methods may not provide sufficient information to evaluate the true nature of these differences. We address these issues by examining the practices for evaluating heterogeneity in anesthesiology reviews. ⋯ Subgroup analysis was used in 59% Cochrane reviews, while sensitivity analysis was used in 62%. Many reviews did not provide sufficient detail regarding heterogeneity. We are calling for improvement to reporting practices.
-
Randomized Controlled Trial
Influence of Bayesian optimization on the performance of propofol target-controlled infusion.
Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do not take into account inter-individual residual variation. This study compares the bias and inaccuracy of a population-based vs a personalized TCI propofol titration using Bayesian adaptation. Haemodynamic and hypnotic stability, and the prediction probability of alternative PK models, was studied. ⋯ Dutch Trial Registry NTR4518.
-
Randomized Controlled Trial
Effect of gum chewing on gastric volume and emptying: a prospective randomized crossover study.