British journal of anaesthesia
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Randomized Controlled Trial Multicenter Study
The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial.
Postoperative delirium occurs frequently in elderly hip fracture surgery patients and is associated with poorer overall outcomes. Because xenon anaesthesia has neuroprotective properties, we evaluated its effect on the incidence of delirium and other outcomes after hip fracture surgery. ⋯ EudraCT 2009-017153-35; ClinicalTrials.gov NCT01199276.
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Multicenter Study Observational Study
Arterial pulse pressure and postoperative morbidity in high-risk surgical patients.
Systemic arterial pulse pressure (systolic minus diastolic pressure) ≤53 mm Hg in patients with cardiac failure is correlated with reduced stroke volume and is independently associated with accelerated morbidity and mortality. Given that deconditioned surgical and heart failure patients share similar cardiopulmonary physiology, we examined whether lower pulse pressure is associated with excess morbidity after major surgery. ⋯ ISRCT registry, ISRCTN88456378.
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Multicenter Study Observational Study
Management of antiplatelet therapy in patients with coronary stents undergoing noncardiac surgery: association with adverse events.
Perioperative discontinuation of antiplatelet therapy (APT) in patients with coronary stents has been associated with major adverse cardiac events. Our aim was to analyse the perioperative management of APT in such patients and its relationship to the incidence of major adverse cardiac and cerebrovascular events (MACCE) and major bleeding events (MBE) in noncardiac surgery. ⋯ NCT01171612.