British journal of anaesthesia
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Letter Observational Study
Residual neuromuscular block in paediatric anaesthesia.
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Randomized Controlled Trial Multicenter Study
Patient coping and expectations predict recovery after major orthopaedic trauma.
Persistent post-surgical pain and associated disability are common after a traumatic fracture repair. Preliminary evidence suggests that patients' beliefs and perceptions may influence their prognosis. ⋯ NCT00788398.
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Observational Study
Development and evaluation of an obstetric quality-of-recovery score (ObsQoR-11) after elective Caesarean delivery.
Whilst validated quality-of-recovery (QoR) tools exist for general surgery, there is no specific obstetric equivalent. We aimed to develop and evaluate a modified QoR score after elective Caesarean delivery. ⋯ The ObsQoR-11 provides a valid, reliable, and responsive global assessment of recovery after elective Caesarean delivery.
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Observational Study
Role of leucocyte caspase-1 activity in epidural-related maternal fever: a single-centre, observational, mechanistic cohort study.
Epidural-related maternal fever (ERMF) has been reported in ∼26% of labouring women. The underlying mechanisms remain unclear. We hypothesised that ERMF is promoted by bupivacaine disrupting cytokine production/release from mononuclear leucocytes [mononuclear fraction (MNF)]. We examined whether bupivacaine (i) reduces caspase-1 activity and release of the anti-pyrogenic cytokine interleukin (IL)-1 receptor antagonist (IL-1ra), and (ii) is pro-inflammatory through mitochondrial injury/IL-1β. ⋯ Impaired release of anti-pyrogenic IL-1ra might explain ERMF mechanistically. Immunomodulation by bupivacaine during labour could promote ERMF.
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Multicenter Study Comparative Study
Using the 6-minute walk test to predict disability-free survival after major surgery.
The 6-min walk test (6MWT) is a common means of functional assessment. Its relationship to disability-free survival (DFS) is uncertain. ⋯ Of the risk assessment tools analysed, the DASI was the most predictive of DFS. The 6MWT was safe and comparable with cardiopulmonary exercise testing for all predictive assessments. Future research should aim to determine the optimal 6MWT distance thresholds for risk prediction.