British journal of anaesthesia
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Review
The case for statin use to reduce perioperative adverse cardiovascular and cerebrovascular events.
Perioperative use of statins in at-risk patients may significantly reduce perioperative stroke and major cardiac events.
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In March 2019, SmartTots, a public-private partnership between the US Food and Drug Administration and the International Anesthesia Research Society, hosted a meeting attended by research experts, anaesthesia journal editors, and government agency representatives to discuss the continued need for rigorous preclinical research and the importance of establishing reporting standards for the field of anaesthetic perinatal neurotoxicity. This group affirmed the importance of preclinical research in the field, and welcomed novel and mechanistic approaches to answer some of the field's largest questions. ⋯ This expert opinion report is a summary of these discussions, and includes a focused review of current animal models and reporting standards for the field of perinatal anaesthetic neurotoxicity. This will serve as a practical guide and road map for novel and rigorous experimental work.
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Review Meta Analysis
Association between night/after-hours surgery and mortality: a systematic review and meta-analysis.
There is an association between after-hours surgery and mortality risk that is not entirely explained by the emergent and morbidity characteristics of patients or the surgical procedure.
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