International journal of clinical practice
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Methadone is an opioid analgesic of step 3 of the World Health Organization (WHO) analgesic ladder. ⋯ Methadone is an important opioid analgesic at step 3 of the WHO analgesic ladder. Future controlled studies may focus on establishment of methadone equianalgesic dose ratio with other opioids and its role as the first strong opioid in comparative studies with analgesia, adverse effects and quality of life taken into consideration.
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Int. J. Clin. Pract. · Jul 2009
ReviewThe therapeutic effect of balneotherapy: evaluation of the evidence from randomised controlled trials.
Systematic review. ⋯ The available data suggest that balneotherapy may be truly associated with improvement in several rheumatological diseases. However, existing research is not sufficiently strong to draw firm conclusions.