International journal of clinical practice
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Int. J. Clin. Pract. · Apr 2021
Randomized Controlled TrialEffect of hearing aids on attention, memory, and auditory evoked potentials: a pragmatic, single-blinded, and randomized pilot clinical trial.
To compare the effects of hearing aids and their technology levels (premium and basic) on attention, memory, brain response, and self-perceived benefit amongst individuals who were naïve to sound amplification. ⋯ In this study, premium and basic hearing aids impacted attention, memory, brain response, and self-perceived benefit similarly amongst individuals who were naïve to sound amplification after 12 weeks of using the hearing devices.
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Int. J. Clin. Pract. · Apr 2021
The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder.
The biological mechanisms underlying major depressive disorder (MDD) are not yet sufficiently understood. The kynurenine pathway has been proposed to play a key role between peripheral inflammation and alterations in the central nervous system. This is because of reduced usability of tryptophan (TRP) and production of oxygen radicals and highly potent neurotoxic agents in this pathway. ⋯ These results suggest that the Kyn and related molecular pathways may play a role in the pathophysiology of MDD. The most important finding was the increased level of QUIN, which has a neurotoxic effect, in the kynurenine pathway.
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Int. J. Clin. Pract. · Apr 2021
Effect of shift work in intensive care on attention disorder in nurses.
The purpose of this study was to determine the level of attention between shifts and to make recommendations about the regulation of shifts. ⋯ This study revealed a significant decrease in the level of attention in the night-shift compared with the day-shift. This increase in attention deficit may also be a preventable cause of increased mortality in the night-shift.
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Int. J. Clin. Pract. · Apr 2021
Location of death among patients presenting with cardiovascular disease to the Emergency Department in the United States.
In-hospital deaths are an important outcome and little is known about deaths in the emergency department (ED). Among patients who died of cardiovascular diseases (CVD), we assessed causes of death, temporal trends and the relative distribution of deaths in the ED versus hospital. ⋯ Inpatient CVD admissions and their associated death may not be a robust measure of the national burden of CVD since ED death-which are common for some conditions-are not captured.
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Int. J. Clin. Pract. · Apr 2021
Assessment of the Relation Between the Neutrophil to Lymphocyte Ratio and Severity of Ischemic Stroke in a Large Cohort.
The NLR is a simple and inexpensive parameter that is useful as a marker of subclinical inflammation. The purpose of this study was to investigate the clinical characteristics of patients diagnosed with acute cerebral ischemia at the time of initial evaluation in the emergency department. ⋯ The NLR exhibited a significant correlation with the results of the mRS and NIHSS. The NLR measured in the very early period was also significantly associated with clinical condition. These results suggest that high NLR values may be a marker of stroke' severity.What's known Stroke is an important disease that has a significant impact on mortality and morbidity and is closely related to the aging world population. In recent years, highly innovative approaches have been developed in the treatment of stroke. Although a long distance has been covered in the early diagnosis of stroke, the ability to predict the severity of the disease with many parameters is still up to date. What's new At the time of admission, in the absence of infection, parameters such as leukocytelymphocyte count and NLR may be telling about stroke severity. Demonstrating the utility of these simple, practical, inexpensive and naninvasive parameters to predict stroke severity can contribute to the scoring to be established at the time of initial diagnosis.