Medical image analysis
-
Medical image analysis · Oct 2014
High-resolution dynamic MR imaging of the thorax for respiratory motion correction of PET using groupwise manifold alignment.
Respiratory motion is a complicating factor in PET imaging as it leads to blurring of the reconstructed images which adversely affects disease diagnosis and staging. Existing motion correction techniques are often based on 1D navigators which cannot capture the inter- and intra-cycle variabilities that may occur in respiration. MR imaging is an attractive modality for estimating such motion more accurately, and the recent emergence of hybrid PET/MR systems allows the combination of the high molecular sensitivity of PET with the versatility of MR. ⋯ On synthetic data with a known ground truth our proposed technique produces significantly better reconstructions than all other examined techniques. On real data without a known ground truth the method gives the most plausible reconstructions and high consistency of reconstruction. Lastly, we demonstrate how our method can be applied for the respiratory motion correction of simulated PET/MR data.