European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
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Eur. J. Paediatr. Neurol. · Jul 2009
Clinical TrialEfficacy of pregabalin in neuropathic pain in paediatric oncological patients.
To evaluate the safety and efficacy of pregabalin in the management of chemotherapy-induced neuropathic pain in patients with childhood solid tumors and leukaemia. ⋯ The treatment with pregabalin resulted in a significant improvement in pain symptoms. The use of pregabalin in children is off-label so far. However, this drug seems to be a safe and effective remedy, which could significantly broaden the therapeutic spectrum in paediatric oncological patients suffering from neuropathic pain.
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Eur. J. Paediatr. Neurol. · Jul 2009
Cerebral infarction and neurodevelopmental outcome in childhood tuberculous meningitis.
Cerebral infarction is an important cause of neurological sequelae in childhood tuberculous meningitis (TBM). ⋯ Infarct characteristics should be taken into account when neurodevelopmental outcome is prognosticated in TBM. Young age, unilateral multiple or bilateral infarction on CT at 1 month, advanced stage of TBM and the interaction term stage x Glasgow coma score are the best predictors of neurodevelopmental outcome at 6 months.