European journal of pain : EJP
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The aim of the present study was to investigate supraspinal modulation of human lower limb reflex receptive fields (RRFs) on the plantar side of the foot during cognitive tasks either distracting the subjects or actively directing their attention to the electrical stimuli directed to the sole of the foot. ⋯ The size of the RRF area was modulated by the cognitive state demonstrating a link between the cognitive activity and the descending control on spinal withdrawal reflex pathways.
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Activation of the prefrontal cortex occurs during acute and chronic pain and models of experimental hyperalgesia. The present study was carried out to determine possible miRNA changes in the prefrontal cortex, after inflammatory pain induced by facial carrageenan injection in mice. miRNA microarray analyses showed significantly increased levels of miR-155 and miR-223 in the prefrontal cortex of carrageenan-injected mice. The changes were verified by real-time RT-PCR, and shown to occur bilaterally. ⋯ Significantly downregulated c/ebp Beta but upregulated GCSF, accompanied by increased immunolabeling with an antibody to myeloperoxidase were found in the prefrontal cortex of facial carrageenan treated mice. It is postulated that this could lead to increased inflammation and activation of the prefrontal cortex. Further studies are necessary to determine if specific miRNAs could be useful as therapeutic molecules for pain.