European journal of pain : EJP
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Elevated depressive symptoms are common in youth with chronic pain, and pain symptoms are frequent in adolescents with depressive disorders. While studies have identified concurrent associations between pain and depression over time in youth, it is unclear how change in one symptom impacts change in the other symptom. ⋯ Findings extend previous adult research to an adolescent sample showing changes in pain intensity are predictive of subsequent depressive symptoms. In comparison to adult data, changes in depressive symptoms had less impact on subsequent pain in youth. Future research can examine how targeting persistent pain may also aid the treatment of depressive symptoms in adolescents.
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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels conduct an inward cation current (Ih ) that contributes to the maintenance of neuronal membrane potential and have been implicated in a number of animal models of neuropathic and inflammatory pain. In the current study, we investigated HCN channel involvement in inflammatory pain of the temporomandibular joint (TMJ). ⋯ Our findings suggest a role for peripheral HCN channels in inflammation-induced pain of the TMJ. Peripheral application of a HCN channel blocker could provide therapeutic benefit for inflammatory TMJ pain and avoid side effects associated with activation of HCN channels in the central nervous system.
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Temporomandibular disorders (TMDs) are clinical problems involving the masticatory muscles and temporomandibular joints (TMJs). Aspects of the aetiology of TMD are controversial. Many studies have identified an association between depression and TMD. The aim of the study was to evaluate the association between both maternal antenatal depression and parental depression during the offspring's childhood with TMD symptoms of the offspring during adulthood and to evaluate the effect of the offspring's own depression on this association. ⋯ The risk for TMD symptoms is not elevated in the offspring of antenatally depressed mothers. Parental depression during an offspring's childhood increases the risk of pain-related TMD symptoms in their early adulthood.
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Inflammation is a major cause of temporomandibular disorder-related pain. The Nav 1.7 sodium channel has a critical function in pain perceptions. However, whether and how Nav 1.7 in the trigeminal ganglion is involved in temporomandibular joint (TMJ) inflammatory pain remains to be examined. ⋯ Trigeminal ganglionic Nav 1.7 has an important function in the hyperalgesia of the inflamed TMJ, which is dependent on the communication with the satellite glials.